IRISH SETTER

Cardiovascular conditions

Persistent right aortic arch (vascular ring anomaly)

• Congenital
• Not all studies confirm predisposition in this breed

Dermatological conditions

Pododermatitis

Primary seborrhoea

• Probably inherited as autosomal recessive

Ichthyosis

• Rare
• Congenital
• Possibly inherited as autosomal recessive

Ehler-Danlos syndrome

Nasal depigmentation

• Also known as Dudley nose

Acral lick dermatitis

• More often seen in males
• Can occur at any age, but usually over 5 years

Callus dermatitis/pyoderma

• Usually affects the sternum in this breed

Greying

• May occur at a young age in this breed

Endocrine conditions

Hypothyroidism

Insulinoma

• Higher incidence seen in this breed
• Usually middle-aged and older dogs

Gastrointestinal conditions

Congenital idiopathic megaoesophagus

• Breed predisposition

Vascular ring anomaly

• Breed predisposition –  inheritance suspected

Gastric dilatation-volvulus

• Breed predisposition

Gluten-sensitive enteropathy

• Breed predisposition

Perianal fistula

Musculoskeletal conditions

Temporomandibular dysplasia/luxation

• Congenital dysplasia may predispose to luxation

Irish Setter hypochondroplasia

• Mildly short limbs seen
• Inherited as autosomal recessive

Canine idiopathic polyarthritis

• Usually affects dogs at 1–3 years, but any age can be affected
• Males predisposed

Neoplastic conditions

Trichoepithelioma

Sebaceous gland tumours

• Possible breed predisposition to sebaceous epithelioma
• Seen in older dogs (average age 10 years)

Haemangiopericytoma

Melanoma

• Breed predisposition
• Average age 8–9 years

Melanoma of the digit

Haematological conditions

Granulocytopathy of Irish Setters

• Inherited as an autosomal recessive trait

Canine leucocyte adhesion deficiency (CLAD)

• Seen in GB and Sweden

Neurological conditions

Cerebellar malformation

• Congenital
• Uncommon

True epilepsy

• Inherited

Lissencephaly

• Rare developmental disease

Ambylopia and quadriplegia

• Autosomal recessive inheritance
• Congenital paralysis and blindness with no visible ocular cause (ambylopia)

Hyperaesthesia syndrome

Ocular conditions

Entropion (usually lower lids)

• Breed predisposition – polygenic inheritance likely

Eversion of the cartilage of the nictitating membrane

• Breed predisposition; possibly inherited as a recessive trait

Refractory corneal ulceration

• Breed predisposition

Glaucoma

Cataract

• Inheritance suspected

Generalised progressive retinal atrophy (GPRA)

• Autosomal recessive inheritance
• A second form of PRA, occurring at 4–5 years, may be seen in this breed

Micropapilla

• Congenital condition

Optic nerve colobomas

• Congenital defect

Ambylopia and quadriplegia

• Autosomal recessive inheritance
• Congenital paralysis and blindness with no visible ocular cause (ambylopia)

Renal and urinary conditions

Urethral sphincter mechanism incompetence (causing urinary incontinence)

• Possible breed predisposition in female dogs

Respiratory conditions

Laryngeal paralysis