Great Dane – Disease Predisposition



Cardiovascular conditions

  • Aortic stenosis
  • Persistent right aortic arch
  • Tricuspid dysplasia
  • Mitral valve dysplasia
  • Dilated cardiomyopathy

Dermatological conditions

  • Muzzle folliculitis/furunculosis
  • Generalised demodicosis
  • Cryptococcosis
  • Colour-dilution alopecia
  • Primary lymphoedema
  • Acral lick dermatitis
  • Callus dermatitis/pyoderma
  • Zinc-responsive dermatosis
  • Idiopathic sterile granuloma and pyogranuloma

Endocrine conditions

  • Hypothyroidism

Gastrointestinal conditions

  • Congenital idiopathic megaoesophagus
  • Gastric dilatation-volvulus
  • Lymphocytic-plasmacytic colitis

Infectious conditions

  • Cryptococcosis – Increased incidence seen in this breed possibly due to an increased likelihood of exposure

Musculoskeletal conditions

  • Central core myopathy
  • Shoulder osteochondrosis
  • Lateral patellar luxation

Neoplastic conditions

  • Canine cutaneous histiocytoma
  • Primary bone tumours (most commonly osteosarcoma)

Neurological conditions

  • Congenital deafness (Harlequin Great Danes)
  • Cervical vertebral malformation (wobbler syndrome)
  • Distal polyneuropathy
  • Hyperaesthesia syndrome

Ocular conditions

  • Entropion (usually lateral lower lids, occasionally lateral upper lids)
  • Ectropion (may be associated with ‘diamond eye’)
  • Combined entropion-ectropion (‘diamond eye’)
  • Medial canthal pocket syndrome – Breed predisposition due to head shape
  • Eversion of the cartilage of the nictitating membrane
  • Primary glaucoma/goniodysgenesis
  • Cataract
  • Generalised progressive retinal atrophy (GPRA)
  • Multiple ocular defects

Reproductive conditions

  • Penile hypoplasia

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