Beagle – Disease Predispositions

Beagle

BEAGLE

  • Pulmonic stenosis
  • Coronary artery vasculitis – reported as affecting  34% of young Beagles
  • Canine juvenile polyarteritis syndrome
  • Congenital hypotrichosis
  • Black hair follicular dysplasia
  • Ehler-Danlos syndrome Also known as cutaneous asthenia
  • Familial vasculopathy
  • Canine truncal solar dermatitis
  • Zinc-responsive dermatosis
  • Lymphocytic thyroiditis (causing hypothyroidism)
  • Thyroid neoplasia (may be associated with hyper- or hypothyroidism, but most are euthyroid)
  • Hyperadrenocorticism: pituitary-dependent (PDH)
  • Diabetes mellitus
  • Chronic hepatitis
  • Severe combined immunodeficiency
  • Selective IgA deficiency – Leads to chronic respiratory conditions and dermatitis
  • Pyruvate kinase deficiency
  • Non-spherocytic haemolytic anaemia
  • Factor VII deficiency
  • Primary idiopathic hyperlipidaemia
  • Polyarthritis/meningitis
  • Multiple epiphyseal dysplasia
  • Brachyury
  • Mast cell tumours
  • Actinic keratosis (solar keratosis)
  • Sebaceous gland tumours
  • Haemangiopericytoma
  • Perianal (hepatoid) gland adenomas
  • Cutaneous haemangioma
  • Thyroid neoplasia
  • Pituitary tumour resulting in hyperadrenocorticism
  • Lymphosarcoma (malignant lymphoma)
  • Congenital vestibular disease
  • Congenital deafness
  • Intervertebral disc disease Relatively common condition
  • Lysosomal storage disease – GM1 gangliosidosis
  • Lysosomal storage disease – neuronal glycoproteinosis (Lafora’s disease)
  • Cerebellar degeneration – reported in Japan
  • True epilepsy
  • Narcolepsy-cataplexy
  • Lissencephaly – a rare disease reported in this breed
  • Hound ataxia Reported in the UK
  • Meningitis and polyarteritis
  • Spina bifida
  • Prolapse of the gland of the nictitating membrane (‘cherry eye’)
  • Corneal dystrophy
  • Stromal lipid dystrophy –  Reports suggest it affects approximately 17% of Beagles aged 8–15 years
  • Glaucoma
  • Lens luxation
  • Cataract
  • Multifocal retinal dysplasia
  • Tapetal degeneration
  • Generalised progressive retinal atrophy (GPRA)
  • Micropapilla
  • Optic nerve hypoplasia
  • Congenital cataract with microphthalmia
  • Microphthalmia-microphakia-persistent pupillary membrane (PPM) syndrome
  • Multiple ocular defects of the posterior segment – Defects include retention of the hyaloid system, excessive myelination of the optic disc and neovascularisation of the retina, with a tendency for intraocular haemorrhage
  • Hypochondroplasia – Accepted as breed standard
  • Renal (glomerular) amyloidosis
  • Unilateral renal agenesis – High prevalence reported in some families of Beagles
  • XX sex reversal

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